zldmЗаводская лаборатория. Диагностика материаловIndustrial laboratory. Diagnostics of materials1028-68612588-0187ООО «Издательство «ТЕСТ-ЗЛ»10.26896/1028-6861-2021-87-3-20-23zldm-1381Research ArticleАНАЛИЗ ВЕЩЕСТВАSUBSTANCES ANALYSISОпределение левамизола с использованием ионоселективного электродаDetermination of levamisole using ion-selective electrodeЗубеняН. В.ZubeniaN. V.

Наталия Владимировна Зубеня

33000, г. Ровно, ул. Николая Карнаухова, д. 53

Natalia V. Zubenia

53, Mykoly Karnaukhova St., Rivne, 33000

natalizubenia@gmail.comКормошЖ. А.KormoshZ. A.

Жолт Александрович Кормош

43025, г. Луцк, проспект Воли, д. 13

Zholt A. Kormosh

13, Voli av., Lutsk, 43025

ХмелярИ. М.KhmeliarI. M.

Инеса Макаровна Хмеляр

33000, г. Ровно, ул. Николая Карнаухова, д. 53

Inesa M. Khmeliar

53, Mykoly Karnaukhova St., Rivne, 33000

СадовникО. В.SadovnykO. V.

Ольга Владимировна Садовник

33000, г. Ровно, ул. Николая Карнаухова, д. 53

Olga V. Sadovnyk

53, Mykoly Karnaukhova St., Rivne, 33000

Ровенская медицинская академияУкраинаRivne Medical AcademyUkraineВосточноевропейский национальный университет имени Леси УкраинкиУкраинаEastern European National UniversityUkraine2021200320218732023Copyright © Зубеня Н.В., Кормош Ж.А., Хмеляр И.М., Садовник О.В., 20212021Зубеня Н.В., Кормош Ж.А., Хмеляр И.М., Садовник О.В.Zubenia N.V., Kormosh Z.A., Khmeliar I.M., Sadovnyk O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.zldm.ru/jour/article/view/1381

Разработан левамизол-селективный электрод с пластифицированной поливинилхлоридной мембраной на основе ионного ассоциата левамизола с бромфеноловым синим. Для моделирования состава мембраны как матрицу использовали ПВХ; в качестве пластификатора исследовали дибутилфталат (ДБФ), диэтилфталат (ДЭФ), диоктилфталат (ДОФ), динонилфталат (ДНФ), дибутилсебацинат (ДБС), трикрезилфосфат (ТКФ). Установлено, что природа пластификатора незначительно влияет на аналитические характеристики электрода. Отклик линеен в диапазоне концентраций 1 · 10–5 – 1 · 10–1 моль/л с крутизной электродной функции 52,1 ± 1,0 мВ/pC. Время отклика электрода составляет 10 с, его можно использовать не менее 8 недель, причем для мембран с большим содержанием пластификатора срок службы электрода дольше. Рабочий диапазон pH 3,0 – 8,0. Были определены потенциометрические коэффициенты селективности электрода по отношению к ряду потенциально мешающих ионов. Разработанный электрод апробирован при определении левамизола в модельных растворах и фармацевтических препаратах («Декарис (Decaris)» и «Левамизол-Здоровье»).

Current development of applied ionometry requires focusing of theoretical studies both on revealing the nature of the selectivity of electrode membranes and on the developing the new methods of membrane synthesis and their modification with the goal of obtaining more perfect structural units with improved functional properties. Elucidation of the relationship between the structural characteristics of the membranes and their effect on the electro-analytical properties is a rather important task. The interaction of organic cation levamisole with bromophenol blue was studied to meet the goals. Levamisole-selective sensor with a plasticized polyvinyl chloride (PVC) membrane has been developed. The electrode contains an ionic associate of levamisole with bromophenol blue. PVC was used as a matrix to model the membrane composition. Membranes plasticized with dibutyl phthalate (DBP), diethyl phthalate (DEP), dioctyl phthalate (DOP), dinonyl phthalate (DNP), dibutyl sebacate (DBP), tricresyl phosphate (TCP) were studied. It was shown that the nature of the plasticizer insignificantly affected the analytical characteristics of the electrode. The response is linear within the concentration range of 1 × 10–5 – 1 ×10–1 mole/liter with the slope of the electrode function 52.1 ± 1.0 mV/pC. The sensor has a quick response (10 sec) and can be used for at least 8 weeks without any divergence in the long run. The operation life of the membranes with a high plasticizer content is much longer. The electrode can be used within pH range of 3.0 – 8.0. Potentiometric selectivity coefficients of the electrode relative to a number of potentially interfering ions were determined. The developed electrode was tested in determination of levamisole in model solutions and pharmaceuticals («Decaris» and «Levamisole-Zdorovye»).

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The authors declare that there are no conflicts of interest present.