zldmЗаводская лаборатория. Диагностика материаловIndustrial laboratory. Diagnostics of materials1028-68612588-0187ООО «Издательство «ТЕСТ-ЗЛ»zldm-197Research ArticleАНАЛИЗ ВЕЩЕСТВАSUBSTANCES ANALYSISЭКСПРЕССНОЕ ОПРЕДЕЛЕНИЕ НИЗКИХ СОДЕРЖАНИЙ МЕТИЛФОСФОНОВОЙ КИСЛОТЫ МЕТОДОМ ВЭЖХ-МС/МСRapid HPLC-MS/MS Determination of Methylphosphonic Acid in Environmental WaterБайгильдиев'Т. М.BaygildievT. M.noemail@neicon.ruРодинИ. А.RodinI. A.noemail@neicon.ruСтаврианидиА. Н.StavrianidiA. N.noemail@neicon.ruБраунА. В.BraunA. V.noemail@neicon.ruАхмероваД. И.AkhmerovaD. I.noemail@neicon.ruШпигунО. А.ShpigunO. A.noemail@neicon.ruРыбальченкоИ. В.RybalchenkoI. V.noemail@neicon.ruМосковский государственный университет им. М. В. ЛомоносоваRussian FederationМосковский государственный университет им. М. В. Ломоносова; Костромской государственный технологический университетRussian FederationКостромской государственный технологический университетRussian Federation20160102201682258Copyright © Байгильдиев' Т.М., Родин И.А., Ставрианиди А.Н., Браун А.В., Ахмерова Д.И., Шпигун О.А., Рыбальченко И.В., 20162016Байгильдиев' Т.М., Родин И.А., Ставрианиди А.Н., Браун А.В., Ахмерова Д.И., Шпигун О.А., Рыбальченко И.В.Baygildiev T.M., Rodin I.A., Stavrianidi A.N., Braun A.V., Akhmerova D.I., Shpigun O.A., Rybalchenko I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.zldm.ru/jour/article/view/197

Разработан экспрессный подход к определению метилфосфоновой кислоты (МФК) - конечного продукта гидролиза нервнопаралитических отравляющих веществ в водных объектах - методом жидкостной хроматографии - тандемной масс-спектрометрии. Выбраны оптимальные условия хроматографического разделения и масс-спектрометрического детектирования. Разработанный способ характеризуется хорошей чувствительностью, точностью, селективностью определения, отсутствием мешающего влияния компонентов основы пробы при анализе природных вод. Способ был опробован при определении МФК в различных реальных водных объектах методом «введено - найдено». При прямом ВЭЖХ-МС/МС определении предел обнаружения МФК в водных объектах составил 10 нг/мл.

New rapid LC-MS/MS approach to determination of methylphosphonic acid (MPA) in environmental waters is developed. MPA is a final product of nerve agent hydrolysis. Optimal conditions of LC separation and MS/MS detection are specified. The developed method is characterized by good sensitivity, precision, selectivity. Matrix component do not interfere with the determination in analysis of natural water samples. The developed approach was tested in analysis of spiked samples of environmental water. The detection limit of MPA direct LC-MS/MS determination in environmental waters is 10 ng/ml.

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The authors declare that there are no conflicts of interest present.