zldmЗаводская лаборатория. Диагностика материаловIndustrial laboratory. Diagnostics of materials1028-68612588-0187ООО «Издательство «ТЕСТ-ЗЛ»10.26896/1028-6861-2023-89-11-5-13zldm-2055Research ArticleАНАЛИЗ ВЕЩЕСТВАSUBSTANCES ANALYSISНецелевой анализ продукции животноводства и кормов на остаточные содержания лекарственных препаратов, пестицидов, микотоксинов и их метаболитов методом масс-спектрометрии высокого разрешения (обзор)Non-target analysis of livestock products and feed for residues of drugs, pesticides, mycotoxins and their metabolites by high-resolution mass spectrometry (a review)КишЛ. К.KishL. K.

Леонид Карольевич Киш

123022, Москва, Звенигородское шоссе, д. 5

 

Leonid K. Kish

5, Zvenigorodskoye shosse, Moscow, 123022

ЛаврухинаО. И.LavrukhinaO. I.

Ольга Игоревна Лаврухина

123022, Москва, Звенигородское шоссе, д. 5

600026, г. Владимир, ул. Горького, д. 87

Olga I. Lavrukhina

5, Zvenigorodskoye shosse, Moscow, 123022

 

hamsster@mail.ruАмелинВ. Г.AmelinV. G.

Василий Григорьевич Амелин

123022, Москва, Звенигородское шоссе, д. 5

Vasiliy G. Amelin

5, Zvenigorodskoye shosse, Moscow, 123022

ТретьяковА. В.TretyakovA. V.

Алексей Викторович Третьяков

123022, Москва, Звенигородское шоссе, д. 5

Alexey V. Tretyakov

5, Zvenigorodskoye shosse, Moscow, 123022

ПеньковТ. Д.Pen’kovT. D.

Тимур Дмитриевич Пеньков

123022, Москва, Звенигородское шоссе, д. 5

Timur D. Pen’kov

5, Zvenigorodskoye shosse, Moscow, 123022

НекрасовД. Ю.NekrasovD. Yu.

Денис Юрьевич Некрасов

123022, Москва, Звенигородское шоссе, д. 5

Denis Yu. Nekrasov

5, Zvenigorodskoye shosse, Moscow, 123022

Всероссийский государственный центр качества и стандартизации лекарственных средств для животных и кормовРоссияThe Russian State Center for Animal Feed and Drug Standardization and QualityRussian FederationВсероссийский государственный центр качества и стандартизации лекарственных средств для животных и кормов ; Владимирский государственный университет им. Александра Григорьевича и Николая Григорьевича СтолетовыхРоссияThe Russian State Center for Animal Feed and Drug Standardization and Quality ; Alexander G. and Nikolay G. Stoletov Vladimir State UniversityRussian Federation2023211120238911513Copyright © Киш Л.К., Лаврухина О.И., Амелин В.Г., Третьяков А.В., Пеньков Т.Д., Некрасов Д.Ю., 20232023Киш Л.К., Лаврухина О.И., Амелин В.Г., Третьяков А.В., Пеньков Т.Д., Некрасов Д.Ю.Kish L.K., Lavrukhina O.I., Amelin V.G., Tretyakov A.V., Pen’kov T.D., Nekrasov D.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.zldm.ru/jour/article/view/2055

Представлен обзор методик нецелевого анализа при одновременной идентификации и определении лекарственных препаратов для ветеринарного применения, пестицидов, микотоксинов, их метаболитов и продуктов трансформации в продукции животноводства с использованием жидкостной хроматографии в сочетании с масс-спектрометрией высокого разрешения. Отмечен ряд ограничений подхода, таких как необходимость использования общих условий извлечения, возможность химических превращений аналитов в процессе пробоподготовки, ложноположительные результаты для изобарных и изомерных соединений и отсутствие спектральных данных для ранее не изученных веществ. Несмотря на это, метод является наиболее перспективным инструментом для определения не выявленных в рамках целевого исследования загрязнителей как в случае многокомпонентного скрининга пищевой продукции и продовольственного сырья, так и при изучении трансформации исходных соединений.

A review of techniques of non-target analysis for simultaneous identification and determination of veterinary drugs, pesticides, mycotoxins, their metabolites, and substances of chemical transformation in livestock products using liquid chromatography and high-resolution mass spectrometry is presented. Some limitations of the approach are noted, such as the necessity of using common extraction conditions, the possibility of analyte transformations during the sample preparation, false positive results for isobaric and isomeric compounds, and the lack of spectral data for previously unexplored substances. However, the method is the most promising tool for the determination of pollutants not identified in the targeted analysis, as in the case of multicomponent screening of food and raw materials, and in the study of the parent compounds transformation.

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The authors declare that there are no conflicts of interest present.