zldmЗаводская лаборатория. Диагностика материаловIndustrial laboratory. Diagnostics of materials1028-68612588-0187ООО «Издательство «ТЕСТ-ЗЛ»zldm-309Research ArticleАНАЛИЗ ВЕЩЕСТВАSUBSTANCES ANALYSISПодавление ионизации как частный случай матричных эффектов в жидкостной хроматографии-масс-спектрометрии (обобщающая статья)Suppression of Ionization as a Particular Case of Matrix Effects in Liquid Chromatography-Mass Spectrometry (generalizing article)ЧерноваЕ. Н.ChernovaE. N.zazhak@hotmail.comРусскихЯ. В.RusskikhYa. V.zazhak@hotmail.comЖаковскаяЗ. А.ZhakovskayaZ. A.zazhak@hotmail.comЛопушанскаяЕ. М.LopushanskayaE. M.lem@b10.vniim.ruГалльН. Р.Gall’N. R.gall@ms.ioffe.ruСанкт-Петербургский научно-исследовательский центр экологической безопасности Российской академии наукRussian FederationВсероссийский Научно-исследовательский институт метрологии им. Д. И. МенделееваRussian FederationФизико-технический институт им. А. Ф. Иоффе Российской академии наук; Институт аналитического приборостроения Российской академии наукRussian Federation2016011020168210516Copyright © Чернова Е.Н., Русских Я.В., Жаковская З.А., Лопушанская Е.М., Галль Н.Р., 20162016Чернова Е.Н., Русских Я.В., Жаковская З.А., Лопушанская Е.М., Галль Н.Р.Chernova E.N., Russkikh Y.V., Zhakovskaya Z.A., Lopushanskaya E.M., Gall’ N.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.zldm.ru/jour/article/view/309

Метод высокоэффективной жидкостной хроматографии-масс-спектрометрии (ВЭЖХ-МС) с ионизацией при атмосферном давлении является одним из наиболее селективных и чувствительных, при этом он, как и другие аналитические методы, подвержен матричным эффектам. Одним из наименее изученных и наиболее непредсказуемым проявлением матричных эффектов при ВЭЖХ-МС анализе является подавление ионизации аналита компонентами матрицы (ion suppression). Поскольку данное явление может оказывать значительное влияние на такие параметры метода, как предел обнаружения, предел определения, точность и воспроизводимость, очевидно, что оценка вклада данного вида матричных эффектов и его учет при количественном анализе необходимы в процессе разработки и валидации методик. В статье обсуждены возможные причины и механизмы возникновения подавления ионизации, приведена максимально сжатая информация об основных подходах к выявлению этого эффекта, путях его минимизации и способах учета при измерениях.

High performance liquid chromatography-mass spectrometry with ionization at atmospheric pressure is one of the most sensitive and selective methods, though, being an analytical technique, it is also greatly subjected to matrix-related effects. Suppression of analyte ionization by matrix components (IS) is one of the least understood and most unpredictable manifestation of the matrix effects in HPLC-MS analysis. As IS can greatly affect the main characteristics of the method - the detection and quantification limits, precision, and reproducibility - evaluation of the contribution and allowance for IS appeared rather important upon development and validation of the methods of analysis. Considerations on the origin and mechanisms of ionization suppression and brief review regarding the major approaches to identification, minimization, and accounting of IS effect in measurements are presented.

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The authors declare that there are no conflicts of interest present.