Ion-selective membrane electrode for diclofenac determination
https://doi.org/10.26896/1028-6861-2020-86-1-5-12
Abstract
A new membrane ion-selective electrode (ISE) based on the use of the diclofenac-toluidine blue ion associate (IA) as an electrode substance (EAS) is developed. It is shown that the optimal concentration of IA in the PVC membrane is 5 – 11%. The effect of the plasticizer content on the linearity and steepness of the electrode function, as well as on the lower limit of diclofenac ion determination is studied. The best ratio of a plasticizer to PVC is (1.0 – 1.5):1. The content of the plasticizer is obviously related to the electrode lifetime which is mainly determined by the frequency of usage being 7.0 – 7.5 months on the average. The best sensor characteristics were obtained using the following composition: ion associate — 7%, dibutyl phthalate — 56%, PVC — 37%. The electrochemical sensor has a linear dynamic range of 5.0 Ч 10–4 – 5.0 Ч 10–2 M, electrode slope of 46.0 mV/pc with a lower detection limit of 3.2 Ч 10–5 M, and response time <15 sec. The low-cost sensor is easy to use, exhibits fast response, wide range of the electrode function linearity, high selectivity to diclofenac and can be used for at least seven weeks. The new method of diclofenac determination is developed and tested on model solutions and pharmaceuticals.
About the Authors
Zholt A. Kormosh
Lesya Ukrainka Eastern European National University
Ukraine
13 Volya Avenue, Lutsk, 43025
Ukraine
13 Volya Avenue, Lutsk, 43025
Irina P. Antal
Lesya Ukrainka Eastern European National University
Ukraine
13 Volya Avenue, Lutsk, 43025
Ukraine
13 Volya Avenue, Lutsk, 43025
References
1. State Pharmacopoeia of Ukraine. 2004. — 672 p.
2. Compendium 2003. Medicinal Products / Ed. by V. N. Kovalenko, A. P. Viktorov. — Kiev: Morion, 2003. — 1388 p.
3. Arcelloni C., Lanzi R., Pedercini S., et al. High-Performance Liquid Chromatographic Determination of Diclofenac in Human Plasma after Solid-Phase Extraction / J. Chromatogr. B. 2001. Vol. 763. P. 195 – 200. DOI: 10.1016/S0378-4347(01) 00383-8.
4. Rośkar R., Kmetec V. Liquid chromatographic determination of diclofenac in human synovial fluid / J. Chromatogr. B. 2003. Vol. 788. N 1. P. 57 – 64. DOI: 10.1016/S1570-0232(02)01015-2.
5. Tubino M., Souza R. L. Gravimetric method for the determination of diclofenac in pharmaceutical preparations / J. AOAC Int. 2005. Vol. 88. N 6. P. 1684 – 1687.
6. Sastry C. S. P., Prasad Tipirneni A. S. R., Suryanarayana M. V. Extractive specrophotomeric determination of some anti-inflammatory agents with methylene violet / Analyst. 1989. Vol. 114. P. 513 – 515. DOI: 10.1039/AN9891400513.
7. Matin A. A., Farajzadeh M. A., Jouyban A. A simple specrophotometric method for determination of sodium diclofenac in pharmaceutical formulations / Il Farmaco. 2005. Vol. 60. N 10. P. 855 – 858. DOI: 10.1016/j.farmac.2005.05.011.
8. Agatonović-Kuštrin S., Živanović Lj., Zečević M., Radulović D. Spectrophotometric study of diclofenac-Fe (III) complex / J. Pharm. Biomed. Anal. 1997. Vol. 16. P. 147 – 153. DOI: 10.1016/S0731-7085(97)00016-2.
9. Botello J. C., Caballero G. P. Spectrophotometric determination of diclofenac sodium with methylene blue / Talanta. 1995. Vol. 42. N 1. P. 105 – 108. DOI: 10.1016/0039-9140(94)00224-G.
10. Souza R. L., Tubino M. Spectrophotometric determination of diclofenac in pharmaceutical preparations / J. Brazil Chem. Soc. 2005. Vol. 16. N 5. P. 1068 – 1073. DOI: 10.1590/S0103- 50532005000600026.
11. Kormosh Zh. O., Hunka I. P., Bazel Ya. R. A new analytical form for the spectrophotometric determination of low levels of diclofenac / Methods and objects of chemical analysis. 2007. Vol. 2. N 1. P. 76 – 81.
12. Kousy N. M. Spectrophotometric and specrtofluorometric determination of etodolac and aceclofenac / J. Pharm. Biomed. Anal. 1999. Vol. 20. N 1 – 2. P. 185 – 194. DOI: 10.1016/S0731- 7085(99)00019-9.
13. Arancibia J. A., Boldrini M. A., Escandar G. M. Spectrofluorimetric determination of diclofenac in the presence of α-cyclodextrin / Talanta. 2000. Vol. 52. N 2. P. 261 – 268. DOI: 10.1016/S0039 – 9140(00)00338 – 6.
14. Damiani P. C., Bearzotti M., Cabezón M. A., Olivieri A. C. Specrtofluorimetric determination of diclofenac in tablets and ointment / J. Pharm. Biomed. Anal. 1999. Vol. 20. N 3. P. 587 – 590. DOI: 10.1016/S0731-7085(99)00052-7.
15. Kormosh Zh. A., Hunka I. P., Bazel Y. R. An ion-selective sensor for assay of diclofenac in medicines / Pharm. Chem. J. 2009. Vol. 43. N 7. P. 428 – 430. DOI: 10.1007/s11094-009- 0311-2.
16. Carreira L. A., Rizk M., El-Shabrawy Y. Europium (III) ion probe spectrofluorometric determination of diclofenac sodium / J. Pharm. Biomed. Anal. 1995. Vol. 13. N 11. P. 1331 – 1337. DOI: 10.1016/0731-7085(95)01567-5.
17. Shamsipur M., Jalali F., Ershad S. Preparation of a diclofenac potentiometric sensor and its application analysis and to drug recovery from biological fluids / J. Pharm. Biomed. Anal. 2005. Vol. 37. N 5. P. 943 – 947. DOI: 10.1016/j.jpba.2004. 07.051.
18. Santini A. O., Pezza H. R., Pezza L. Determination of diclofenac in pharmaceutical preparations using a potentiometric sensor immobilized in a graphite matrix / Talanta. 2006. Vol. 68. N 3. P. 636 – 642. DOI: 10.1016/j.talanta.2005.05.016.
19. Hassan S. S. M., Mahmoud W. H., Elmosallam M. A. F., Almarzooqi M. H. Iron (II)-phthalocyanine as a novel recognition sensor for selective potentiometric determination of diclofenac and warfarin drugs / J. Pharm. Biomed. Anal. 2005. Vol. 39. N 1 – 2. P. 315 – 321. DOI: 10.1016/j.jpba.2005.03.027.
20. Kormosh Zh., Hunka I., Bazel Ya., et al. Determination of diclofenac in pharmaceuticals and urine samples using a membrane sensor based on the ion associate of diclofenac with Rhodamine B / Cent. Eur. J. Chem. 2007. Vol. 5. N 3. P. 813 – 823. DOI: 10.2478/s11532-007-0024-x.
21. Kormosh Zh., Hunka I., Bazel Ya. Spectrophotometric determination of ketoprofen and its application in pharmaceutical analysis / Acta Poloniae Pharmaceutica — Drug Research. 2009. Vol. 66. N 1. P. 3 – 9.
22. Kormosh Zh., Hunka I., Bazel Y. Potentiometric sensor for the indomethacin determination / Mater. Sci. Eng. C. 2009. Vol. 29. P. 1018 – 1022. DOI: 10.1016/j.msec.2008.09.003.
23. Kormosh Zh. A., Hunka I. P., Bazel Ya. R. A Potentiometric Sensor for the Determination of Diclofenac / J. Anal. Chem. 2009. Vol. 64. N 8. P. 853 – 858. DOI: 10.1134/ S1061934809080140.
24. Kormosh Zh., Savchuk T., Korolchuk S., Bazel Ya. Design and application of triiodide-selective membrane electrode / Electroanalysis. 2011. Vol. 23. N 9. P. 2144 – 2147. DOI: 10.1002/ elan.201000737.
25. Kormosh Zh., Matviychuk O. Potentiometric determination of mefenamic acid in pharmaceutical formulation by membrane sensor based on ion-pair with basic dye / Chin. Chem. Lett. 2013. Vol. 24. N 4. P. 315 – 317. DOI: 10.1016/j.cclet.2013. 03.001.
26. Kormosh Zh. A., Savchuk T. I., Bazel Ya. R. The potentiometric sensor for determination of pentachlorophenol in Water / J. Water Chem. Technol. 2013. Vol. 32. N 4. P. 152 – 158. DOI: 10.3103/S1063455X13040024.
27. Bayulesku G., Koshofrets V. Application of ion-selective membrane electrodes in organic analysis. — Moscow: Mir, 1980. — 230 p. [Russian translation].
28. Camman K. Work with ion-selective electrodes. — Moscow: Mir, 1980. — 283 p. [Russian translation].
29. Morf W. E. The principles of ion-selective electrodes and of membrane transport. — Budapest: Akademiai Kiado, 1981.
30. Kulapina E. G., Baritonova O. V. Ion-selective electrodes for determination of nitrogen-containing medicines / J. Anal. Chem. 2001. Vol. 56. N 5. P. 457 – 460. DOI: 10.1023/A: 1016683121191.
31. Nyzhnikova E. V., Podterob A. P. Potentiometric determination of solubilities of physiologically active amine salts / Pharm. Chem. J. 2004. Vol. 38. N 9. P. 504 – 507. DOI: 10.1007/s11094- 004-009-4.
Review
For citations:
Kormosh Zh.A., Antal I.P. Ion-selective membrane electrode for diclofenac determination. Industrial laboratory. Diagnostics of materials. 2020;86(1):5-12. (In Russ.) https://doi.org/10.26896/1028-6861-2020-86-1-5-12
Views:
628
Email this article 