The effect of magnetic nanoparticles and cetylpyridinium chloride on the electroanalytical properties of planar sensors sensitive to cefuroxime and cefotaxime

Planar screen-printed potentiometric sensors sensitive to cephalosporin antibiotics cefuroxime (Cefur) and cefotaxime (Ceftx) has been developed. Cefotaxime is an amphoteric antibiotic with carboxyl and aminothiazole groups (third generation), cefuroxime is an acidic antibiotic of the second generation. Tetradecylammonium associates with complex compounds silver (I)-cefuroxime (cefotaxime) were used as electrode-active components (EAC). The linearity intervals of the electrode functions for unmodified sensors are 1 × 10^–5 (1 × 10^–4) – 1 × 10^–2 M, angular coefficients 46 ± 6 mV/pC, response time 40 sec. The role of magnetic nanoparticles Fe₃O₄ and cetylpyridinium chloride (CPCh) in improving the electroanalytical properties of sensors in aqueous of cefuroxime and cefotaxime is shown. Optimal ratios of modifiers in carbon-containing inks (Fe₃O₄:CPCh = 1:2.5) were found. The main electroanalytical characteristics of the sensors are determined. The introduction of a binary mixture of magnetic nanoparticles and cetylpyridinium chloride into carbon-containing inks leads to an improvement in the electroanalytical properties of planar sensors sensitive to cefuroxime and cefotaxime: at the same time, the detection limit of 1 × 10^–6 (1 × 10^–7 M) decreases, angular coefficients (55 ± 3 mV/pC) and linearity intervals of the electrode functions (1 × 10^–6 – 1 × 10^–2 M), response time 26 – 30 sec. The adsorption of surfactants at the interface ensures the stability of the suspension of nanoparticles and allows the concentration of analyte molecules. Electrostatic and hydrophobic interactions of surfactants increase the solubility of organic compounds. The use of modified screen-printed sensors for the determination of cefuroxime and cefotaxime in medicinal preparations and model aqueous with added antibiotics is shown.

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