Влияние магнитных наночастиц и хлорида цетилпиридиния на электроаналитические свойства планарных сенсоров, чувствительных к цефуроксиму и цефотаксиму

Разработаны планарные потенциометрические сенсоры, чувствительные к цефалоспориновым антибиотикам — цефуроксиму и цефотаксиму. В качестве электродно-активных компонентов использованы ассоциаты тетрадециламмония с комплексными соединениями серебро (I)-цефуроксим (цефотаксим). Интервалы линейности электродных функций для немодифицированных сенсоров — 1 · 10^–5 (1 · 10^–4) – 1 · 10^–2 моль/л, угловые коэффициенты — 46 ± 6 мВ/pC, время отклика — 40 с. Показана роль магнитных наночастиц Fe₃O₄ и хлорида цетилпиридиния (ЦПХ) в улучшении электроаналитических свойств сенсоров в растворах цефуроксима и цефотаксима. Найдены оптимальные соотношения модификаторов в углеродсодержащих чернилах (Fe₃O₄:ЦПХ = 1:2,5). Определены основные электроаналитические характеристики модифицированных сенсоров: введение в углеродсодержащие чернила бинарной смеси магнитных наночастиц и хлорида цетилпиридиния приводит к снижению предела обнаружения цефуроксима и цефотаксима до 1 · 10^–6 (1 · 10^–7 моль/л), увеличению угловых коэффициентов (55 ± 3 мВ/pC) и интервалов линейности электродных функций (1 · 10^–6 – 1 · 10^–2 моль/л), снижению времени отклика до 26 – 30 с. Адсорбция ПАВ на границе раздела фаз обеспечивает стабильность суспензии наночастиц и позволяет провести концентрирование молекул аналита. Электростатические и гидрофобные взаимодействия с ПАВ увеличивают растворимость органических соединений. Показано применение модифицированных «screen-printed» сенсоров для определения цефуроксима и цефотаксима в лекарственных препаратах и модельных водных растворах с внесенными добавками антибиотиков.

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