Нецелевой анализ продукции животноводства и кормов на остаточные содержания лекарственных препаратов, пестицидов, микотоксинов и их метаболитов методом масс-спектрометрии высокого разрешения (обзор)

Представлен обзор методик нецелевого анализа при одновременной идентификации и определении лекарственных препаратов для ветеринарного применения, пестицидов, микотоксинов, их метаболитов и продуктов трансформации в продукции животноводства с использованием жидкостной хроматографии в сочетании с масс-спектрометрией высокого разрешения. Отмечен ряд ограничений подхода, таких как необходимость использования общих условий извлечения, возможность химических превращений аналитов в процессе пробоподготовки, ложноположительные результаты для изобарных и изомерных соединений и отсутствие спектральных данных для ранее не изученных веществ. Несмотря на это, метод является наиболее перспективным инструментом для определения не выявленных в рамках целевого исследования загрязнителей как в случае многокомпонентного скрининга пищевой продукции и продовольственного сырья, так и при изучении трансформации исходных соединений.

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