The Use of Tandem Mass Spectrometry of High-Resolution with Data-Dependent Acquisition for Verification of the Authenticity of Peptide and Protein Drugs

The use of high-resolution mass spectrometry in data dependent acquisition mode is presented for assessing the authenticity of peptide and protein based drugs. The parameters of mass spectrometric detection (e.g., capillary potential and temperature, range of the detected ions, ion population, maximum ion injection time for MS/MS, ranges of the ion charge state and mass variation, duration of dynamic exclusion, impact energy, isolation width) are specified.

human recombinant insulin, human somatotropic recombinant hormone, high performance liquid chromatography, mass spectrometry, data dependent acquisition mode, рекомбинантный инсулин человека, рекомбинантный соматотропный гормон человека, высокоэффективная жидкостная хроматография, масс-спектрометрия, интеллектуальное управление измерениями

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