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Screening and simultaneous determination of 80 veterinary drugs residues in food by HPLC-MS/MS
https://doi.org/10.26896/1028-6861-2023-89-8-12-22
Abstract
A fast method of samples screening and determination of 80 veterinary drugs residues in food safety assessment is proposed. The solid-phase extraction for the extract purification in the sample preparation is excluded, at the same time the matrix effect is mitigated by the isotope-labeled standards using. The isotope dilution method allowed to exclude matrix calibration curves construction and calculate the concentration using correction coefficients found from analytes standard aqueous solutions and a limited number of isotope-labeled standards. The drugs residues limits of detection (cmin = 0,1 – 10 ng/g) allowed their determination at the maximum permissible levels for food.
About the Authors
V. G. Amelin
The Russian State Center for Animal Feed and Drug Standardization and Quality
Russian Federation
Russian Federation
Vasiliy G. Amelin
5, Zvenigorodskoye shosse, Moscow, 123022
I. V. Batov
The Russian State Center for Animal Feed and Drug Standardization and Quality
Russian Federation
Russian Federation
Ilya V. Batov
5, Zvenigorodskoye shosse, Moscow, 123022
O. I. Lavrukhina
The Russian State Center for Animal Feed and Drug Standardization and Quality
Russian Federation
Russian Federation
Olga I. Lavrukhina
5, Zvenigorodskoye shosse, Moscow, 123022
A. V. Tretyakov
The Russian State Center for Animal Feed and Drug Standardization and Quality
Russian Federation
Russian Federation
Alexey V. Tretyakov
5, Zvenigorodskoye shosse, Moscow, 123022
L. K. Kish
The Russian State Center for Animal Feed and Drug Standardization and Quality
Russian Federation
Russian Federation
Leonid K. Kish
5, Zvenigorodskoye shosse, Moscow, 123022
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Review
For citations:
Amelin V.G., Batov I.V., Lavrukhina O.I., Tretyakov A.V., Kish L.K. Screening and simultaneous determination of 80 veterinary drugs residues in food by HPLC-MS/MS. Industrial laboratory. Diagnostics of materials. 2023;89(8):12-22. (In Russ.) https://doi.org/10.26896/1028-6861-2023-89-8-12-22
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