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Подавление ионизации как частный случай матричных эффектов в жидкостной хроматографии-масс-спектрометрии (обобщающая статья)

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Аннотация

Метод высокоэффективной жидкостной хроматографии-масс-спектрометрии (ВЭЖХ-МС) с ионизацией при атмосферном давлении является одним из наиболее селективных и чувствительных, при этом он, как и другие аналитические методы, подвержен матричным эффектам. Одним из наименее изученных и наиболее непредсказуемым проявлением матричных эффектов при ВЭЖХ-МС анализе является подавление ионизации аналита компонентами матрицы (ion suppression). Поскольку данное явление может оказывать значительное влияние на такие параметры метода, как предел обнаружения, предел определения, точность и воспроизводимость, очевидно, что оценка вклада данного вида матричных эффектов и его учет при количественном анализе необходимы в процессе разработки и валидации методик. В статье обсуждены возможные причины и механизмы возникновения подавления ионизации, приведена максимально сжатая информация об основных подходах к выявлению этого эффекта, путях его минимизации и способах учета при измерениях.

Об авторах

Е. Н. Чернова
Санкт-Петербургский научно-исследовательский центр экологической безопасности Российской академии наук
Россия


Я. В. Русских
Санкт-Петербургский научно-исследовательский центр экологической безопасности Российской академии наук
Россия


З. А. Жаковская
Санкт-Петербургский научно-исследовательский центр экологической безопасности Российской академии наук
Россия


Е. М. Лопушанская
Всероссийский Научно-исследовательский институт метрологии им. Д. И. Менделеева
Россия


Н. Р. Галль
Физико-технический институт им. А. Ф. Иоффе Российской академии наук; Институт аналитического приборостроения Российской академии наук
Россия


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Для цитирования:


Чернова Е.Н., Русских Я.В., Жаковская З.А., Лопушанская Е.М., Галль Н.Р. Подавление ионизации как частный случай матричных эффектов в жидкостной хроматографии-масс-спектрометрии (обобщающая статья). Заводская лаборатория. Диагностика материалов. 2016;82(10):5-16.

For citation:


Chernova E.N., Russkikh Y.V., Zhakovskaya Z.A., Lopushanskaya E.M., Gall’ N.R. Suppression of Ionization as a Particular Case of Matrix Effects in Liquid Chromatography-Mass Spectrometry (generalizing article). Industrial laboratory. Diagnostics of materials. 2016;82(10):5-16. (In Russ.)

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