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DETERMINATION OF DIPHENHYDRAMINE HYDROCHLORIDE IN PHARMACEUTICALS USING SOLID-PHASE SPECTROPHOTOMETRY

https://doi.org/10.26896/1028-6861-2017-83-12-21-23

Abstract

A method for determination of diphenhydramine hydrochloride (DH) in pharmaceuticals using solid-phase spectrophotometry is presented. The method is based on DH extraction in the form of an ion associate with acidic dye (sulfonazo) from the solution on polyurethane foam.

About the Authors

M. M. Osmanova
Dagestan State University, Makhachkala
Russian Federation


Kh. A. Mirzaeva
Dagestan State University, Makhachkala
Russian Federation


References

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2. Mamina E. A., Bolotov V. V., Bondar’ V. S. The use of azo dye based on teofillina for chemical and toxicological analysis of diphenhydramine, promedol, fentanyl and cyclodolum / Khim.-farm. zh. 2002. Vol. 36. N 5. P. 46 – 49 [in Russian].

3. Mirzaeva Kh. A., Akhmedova M. S., Ramazanov A. Sh, Akhmedov S. A. Extraction-photometric determination of dimedrol and papaverine in pharmaceutical dosage forms / J. Anal. Shem. 2004. Vol. 59. N 3. P. 215 – 218.

4. RF Pat. No. 2237237 G 01 N 21/78. Determination of diphenhydramine hydrochloride, or papaverine / Akhmedova M. S., Mirzaeva Kh. A., Ramazanov A. Sh.; applicant and owner Dagestanskii gosudarstvennyi universitet. — appl. 04.12.2002, publ. 27.09.2004 [in Russian].

5. Mirzaeva Kh. A., Kimpaeva M. M. Application of diffuse reflectance spectroscopy for the quantitative determination of diphenhydramine / «Lomonosov-2013»: materials of the international youth forum. April 08 – 12, 2013. Moscow, M. V. Lomonosov Moscow State University [in Russian].

6. Dmitrienko S. G., Zolotov Yu. A. Polyurethane foams in chemical analysis: sorption of various substances and its analytical applications / Rus. Chem. Rev. 2002. Vol. 71. N 2. P. 159 – 174.

7. RF Pat. No. 2498295 G 01 N 31122. Determination of diphenhydramine hydrochloride / Kimpaeva M. M., Mirzaeva Kh. A.; applicant and owner Dagestanskii gosudarstvennyi universitet. — appl. 05.10.2012, publ. 10.11.2013 [in Russian].


Review

For citations:


Osmanova M.M., Mirzaeva Kh.A. DETERMINATION OF DIPHENHYDRAMINE HYDROCHLORIDE IN PHARMACEUTICALS USING SOLID-PHASE SPECTROPHOTOMETRY. Industrial laboratory. Diagnostics of materials. 2017;83(12):21-23. (In Russ.) https://doi.org/10.26896/1028-6861-2017-83-12-21-23

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ISSN 1028-6861 (Print)
ISSN 2588-0187 (Online)